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Contraindicated (1)pentobarbital will lessen the level or influence of lumacaftor/ivacaftor by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or influence of exemestane by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. For people obtaining exemestane with a strong CYP3A4 indu